Prometrium (Progesterone) is a female hormone used to protect the lining of the uterus in women on estrogen replacement therapy.

Use Prometrium as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Prometrium . Talk to your pharmacist if you have questions about this information.

Take Prometrium by mouth with or without food.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloating; breast tenderness; diarrhea; dizziness; drowsiness; dry mouth; fluid retention; headache; heartburn; irritability; muscle pain; nausea; stomach pain or cramping; tiredness; vomiting.

This is not a complete list of all side effects that may occur. Consult your health care professional for more information.

Some MEDICINES MAY INTERACT with Prometrium . Tell your health care provider if you are taking any other medicines, especially any of the following:

Rifampin because it may decrease Prometrium 's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Prometrium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

If overdose is suspected, contact your local poison control center or emergency room immediately.

Symptoms of overdose may include nausea, vomiting, sleepiness, and dizziness.

This product has peanut oil in it. Do not take Prometrium if you are allergic to peanuts.

Diabetes patients - Prometrium may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Prometrium may increase your risk of developing blood clots. If you will be having surgery or be confined to a bed or chair for a long period of time (such as a long plane flight), notify your doctor beforehand. Special precautions may be needed in these circumstances while you are taking Prometrium .
Prometrium may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Prometrium .

If you miss a dose of Prometrium , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Prometrium .

This medicine is a female hormone used to protect the lining of the uterus in women on estrogen replacement therapy. Progesterone may lower the risk of estrogen-related cancer of the uterus. This medicine is also used to treat women who have had menstrual periods in the past but have stopped having them because of a lack of progesterone hormone.

This medicine may also be used to treat other conditions as determined by your doctor.

Store Prometrium at 77 degrees F / 25 degrees C in a tight, light-resistant container.

Store away from heat, moisture, and light.

Lab tests, including monthly breast self-exams, yearly breast exams, Pap smears, and pelvic exams, may be performed while you use Prometrium . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Prometrium should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: Do not use Prometrium if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Prometrium is found in breast milk. If you are or will be breast-feeding while you use Prometrium , check with your doctor. Discuss any possible risks to your baby.