Use Pyrazinamide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild joint or muscle pain or tenderness.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; fever; general feeling of being unwell; loss of appetite; nausea; pain or swelling in the joints; severe dizziness; stomach pain; trouble breathing; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

alcohol
allopurinol
colchicine
probenecid
sulfinpyrazone

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products.

Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs.

These may affect the way your medicine works.

Check with your health care professional before stopping or starting any of your medicines.

If overdose is suspected, contact your local poison control center or emergency room immediately.

Some MEDICINES MAY INTERACT with Pyrazinamide . Tell your health care provider if you are taking any other medicines, especially any of the following:

Rifampin because the risk of serious liver side effects may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyrazinamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Do not take a double dose to make up for a missed one.

Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Store at room temperature between 15 and 30 degrees C / 59 and 86 degrees F.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances

if you have kidney or liver disease, the blood disease porphyria, diabetes, or HIV

if you regularly consume alcohol-containing beverages or have a history of alcoholism