Evista may increase the risk of serious blood clots. Do not take Evista if you have a history of serious blood clots (eg, in the lung, leg, or eye).

Evista may increase the risk of death from stroke in patients who have coronary heart disease or who are at risk for certain serious heart problems. If you have heart problems or are at risk for a serious heart problem, talk with your doctor to be sure that the benefits of using Evista outweigh the risks.


Raloxifene (Evista) is a selective estrogen receptor modulator (SERM).

Use Raloxifene (Evista) as directed by your doctor.

Take Raloxifene (Evista) by mouth with or without food.

Ask your health care provider any questions you may have about how to use Raloxifene (Evista).

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hot flashes; increased sweating; joint aches; leg cramps.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; back or side pain; blurred vision, loss of vision, or other vision changes; breast pain, tenderness, swelling, lump or discharge; chest pain; coughing up blood; confusion; flu-like symptoms; leg or calf pain, warmth, or swelling; one-sided weakness; shortness of breath; slurred speech; swelling of the hands, arms, legs or feet; unexplained bleeding.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider.

Tell your health care provider if you are taking any other medicines, especially any of the following:

Anion exchange resins (eg, cholestyramine) because they may decrease Evista 's effectiveness
Diazepam, diazoxide, or lidocaine because the risk of their side effects may be increased by Raloxifene (Evista).
Anticoagulants (eg, warfarin) because their effectiveness may be decreased by Evista

This may not be a complete list of all interactions that may occur. Ask your health care provider if Evista may interact with other medicines that you take.

If overdose is suspected, contact your local poison control center or emergency room immediately.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of liver problems, kidney problems, breast cancer, or any other type of cancer

if you have a history of stroke, transient ischemic attack (TIA), blood vessel problems, heart problems, (eg, heart failure, irregular heartbeat), or high blood pressure

if you are at risk for stroke or heart problems

if you will be having surgery, you smoke or drink alcohol, you are not able to absorb nutrients properly (gastrointestinal malabsorption syndrome), or you have very poor health

if you are taking an estrogen or have a history of high triglyceride levels while taking an estrogen

if anyone in your family has a history of serious blood clots

Do not double doses to make up for a misse dose.

Treating and preventing osteoporosis (bone thinning) in women who are past menopause.

Raloxifene (Evista) is also used to reduce the risk of invasive breast cancer in certain women who are past menopause.

Ask your doctor or pharmacist for more information.

Store at room temperature away from heat and light.

Follow the diet and exercise program given to you by your health care provider.

Tell your doctor or dentist that you take Raloxifene (Evista) before you receive any medical or dental care, emergency care, or surgery. Tell your doctor if you will be traveling, or any other time you may be confined to a bed or chair.

Raloxifene (Evista) is not recommended for use in men.

Be sure to keep all doctor and lab appointments.