Vytorin is a combination of 2 medicines.

Ezetimibe works by reducing the amount of cholesterol that your body absorbs from your diet. Simvastatin is an HMG-CoA reductase inhibitor.

Take Vytorin exactly as directed.

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Flu-like symptoms; headache; pain in the arms or legs; tiredness; upper respiratory tract infection.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or vision changes; change in the amount of urine; chest pain; dark urine; fast heartbeat; fever; loss of appetite; muscle tenderness, pain, or weakness; nausea; stomach tenderness; unexplained pain in the stomach or mid-upper back; unusual bruising or bleeding; unusual tiredness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider.

Tell your health care provider if you are taking any other medicines, especially any of the following:

Bosentan, carbamazepine, cholestyramine, hydantoins (eg, phenytoin), rifampin, or St. John's wort because they may decrease Vytorin 's effectiveness
Amiodarone, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), cyclosporine, danazol, delavirdine, diltiazem, fibrates (eg, clofibrate, fenofibrate), fluconazole, gemfibrozil, HIV protease inhibitors (eg, ritonavir), imatinib, itraconazole, ketoconazole, macrolide antibiotics (eg, erythromycin), macrolide immunosuppressives (eg, tacrolimus), mibefradil, nefazodone, streptogramins, telithromycin, verapamil, or voriconazole because side effects, such as muscle pain, may occur
Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Vytorin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vytorin may interact with other medicines that you take.

If overdose is suspected, contact your local poison control center or emergency room immediately.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are a woman of childbearing age

if you have kidney problems, muscle problems or a family history of muscle problems, low blood pressure, uncontrolled seizures, or serious metabolic, endocrine, or electrolyte problems

if you are scheduled for major surgery, have recently had a major trauma, or have a severe infection or history of alcohol abuse

if you have had an organ transplant and are taking medicine to suppress a rejection reaction

Do not double dose to make up for a missed dose.

Treating high cholesterol along with a cholesterol-lowering diet.

Ask your doctor or pharmacist for more information.

Store it at room temperature and away from excess heat and moisture.

Proper dental care is important while you are taking Vytorin.

Vytorin may harm your liver. Inform your health care professional if you drink alcohol while you are using Vytorin.

If you have any questions about Vytorin, please talk with your doctor, pharmacist, or other health care provider.