Irbesartan and hydrochlorothiazide (Avalide) can cause injury or even death to a developing fetus when used after the third month of pregnancy. Contact your doctor immediately if you suspect that you are pregnant.


Irbesartan and hydrochlorothiazide (Avalide) is a combination angiotensin II receptor blocker and diuretic.

Take Irbesartan and hydrochlorothiazide (Avalide) exactly as directed.

Your doctor may have also prescribed a potassium supplement for you.

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decrease in sexual ability; depression; drowsiness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; decreased urination; hoarseness; muscle pain, tenderness, or cramps; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent dry mouth; severe or persistent vomiting; shortness of breath; swelling of the arms or legs; unusual bruising or bleeding; unusual thirst; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider.

Tell your health care provider if you are taking any other medicines, especially any of the following:

Dofetilide or ketanserin because the risk of irregular heartbeat may be increased
Adrenocorticotropic hormone (ACTH), barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), diuretics (eg, furosemide), narcotic pain medicines (eg, morphine), or other medicines for high blood pressure because they may increase the risk of Irbesartan and hydrochlorothiazide (Avalide)'s side effects
Cholestyramine, colestipol, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because they may decrease Irbesartan and hydrochlorothiazide (Avalide)'s effectiveness
Diazoxide, digoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), potassium, or potassium-sparing diuretics (eg, spironolactone) because risk of their side effects and toxic effects may be increased by Irbesartan and hydrochlorothiazide (Avalide)
Diabetes medicine (eg, glipizide, metformin), insulin, or pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Irbesartan and hydrochlorothiazide (Avalide)

This may not be a complete list of all interactions that may occur. Ask your health care provider if Irbesartan and hydrochlorothiazide (Avalide) may interact with other medicines that you take.

In case of overdose, call your local poison control center at 1-800-222-1222.

If the victim has collapsed or is not breathing, call local emergency services at 911.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are planning to become pregnant or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have ever had a severe reaction (eg, swelling of the hands, face, lips, eyes, throat, or tongue; trouble swallowing or breathing; hoarseness) after taking any other angiotensin II receptor blocker or an angiotensin converting enzyme (ACE) inhibitor (eg, captopril)

if you are dehydrated; have low blood volume; have low blood sodium, chloride, potassium, or magnesium levels; or have high blood calcium levels

if you have asthma; diabetes; gout; heart problems (eg, congestive heart failure); liver, gall bladder, or kidney problems; high blood cholesterol or lipid levels; or systemic lupus erythematosus

if you have recently had nerve surgery

Do not take a double dose to make up for a missed one.

Treating high blood pressure.

Irbesartan and hydrochlorothiazide (Avalide) may be prescribed for other uses; ask your doctor or pharmacist for more information.

STORE THIS MEDICINE at room temperature away from heat and light.

Wear disease medical alert identification for high blood pressure.

Tell your doctor or dentist that you take Avalide before you receive any medical or dental care, emergency care, or surgery.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines.

Diabetes patients - Irbesartan and hydrochlorothiazide (Avalide) may affect your blood sugar.

If you have any questions about Irbesartan and hydrochlorothiazide (Avalide), please talk with your doctor, pharmacist, or other health care provider.