Adapalene (Differin) is a retinoid-like compound.

Use Adapalene (Differin) as directed by your doctor.

Do not use other medicines on your skin without first discussing it with your doctor.

Do not apply Adapalene (Differin) to cuts, abrasions, eczematous skin, or sunburned skin.

Ask your health care provider any questions you may have about how to use Adapalene (Differin).

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary burning and stinging; dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider.

Some MEDICINES MAY INTERACT with Adapalene (Differin). Because little, if any, of Adapalene (Differin) is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Adapalene (Differin) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

If overdose is suspected, contact your local poison control center or emergency room immediately.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have eczema or sunburn

Do not double applications to make up for a missed application.

Treating severe acne.

Adapalene (Differin) may also be used for other conditions as determined by your doctor.

Store at room temperature away from heat and light.

Adapalene (Differin) may cause you to become sunburned more easily.

Skin moisturizers may be used if necessary. Do not use moisturizers that contain alpha hydroxy or glycolic acids.

Certain cosmetic procedures, such as waxing, should not be performed on treated skin due to possible irritation.

If you have any questions about Adapalene (Differin), please talk with your doctor, pharmacist, or other health care provider.